Research Interests

Neuroimage analyses in neurodegenerative diseases in humans using MRI, fMRI, and PET

• To discover disease-related biomarkers using multimodal brain imaging data and to develop a brain network model for degenerative diseases

• To characterize brain networks via in-depth analyses and explore disease-specific changes for prediction and early diagnosis of diseases

• To understand pathological mechanisms by discovering disease biomarkers

• To establish a systemic and efficient diagnostic model by conducting various brain network analyses in relations to functional and behavioral data

Publications

• Joon Hyung Jung, Ga Won Lee, Jun Ho Lee, Min Soo Byun, Dahyun Yi, So Yeon Jeon, Gi Jung Jung, Haejung Joung, Seong A Shin, Yu Kyeong Kim, Koung Mi Kang, Chul-Ho Sohn, Dong Young Lee, for the KBASE Research Group. Multiparity, brain atrophy, and cognitive decline. Frontiers in Aging Neuroscience, Vol. 12(159), June 2020

• Jee Wook Kim, Min Soo Byun, Dahyun Yi, Jun Ho Lee, So Yeon Jeon, Kang Ko, Gijung Jung, Han Na Lee, Jun-Young Lee, Chul-Ho Sohn, Yun-Sang Lee, Seong A Shin, Yu Kyeong Kim, Dong Young Lee, and for the KBASE Research Group. Serum uric acid, Alzheimer-related brain changes, and cognitive impairment. Frontiers in Aging Neuroscience, Vol. 12(160). June 2020

• Min Soo Byun, Joon Hyung Jung, Bo Kyung Sohn, Dahyun Yi, Jun Ho Lee, So Yeon Jeon, Younghwa Lee, Gi Jung Jung, Jun‐Young Lee, Yu Kyeong Kim, Seong A Shin, Chul‐Ho Sohn, Koung Mi Kang, Dong Young Lee, for the KBASE Research Group. Neuroticism, conscientiousness, and in vivo Alzheimer pathologies measured by amyloid PET and MRI. Psychiatry and Clinical Neuroscience, Vol. 74(5). May 2020

• Seung Hoon Lee, Min Soo Byun, Jun Ho Lee, Dahyun Yi, Bo Kyung Sohn, Jun-Young Lee, Yu Kyeong Kim, Seong A Shin, Chul-Ho Sohn, Dong Young Lee, for the KBASE ResearchGroup. Sex-Specific Association of Lifetime Body Mass Index with Alzheimer's Disease Neuroimaging Biomarkers. Journal of Alzheimer's Disease, Vol. 75(3). April 2020

• Jee Wook Kim, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Kang Ko, So Yeon Jeon, Bo Kyung Sohn, Jun-Young Lee, Yu Kyeong Kim, Seong A Shin, Chul-Ho Sohn, Dong Young Lee, KBASE Research Group. Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study. PLoS Medicine, Vol. 17(2). February 2020

• Jee Wook Kim, Min Soo Byun, Dahyun Yi, Jun Ho Lee, So Yeon Jeon, Gijung Jung, Han Na Lee, Bo Kyung Sohn, Jun-Young Lee, Yu Kyeong Kim, Seong A Shin, Chul-Ho Sohn, Dong Young Lee, for the KBASE Research Group. Coffee intake and decreased amyloid pathology in human brain. Translational Psychiatry, Vol. 9(1), October 2019

• Young Min Choe, Min Soo Byun, Dahyun Yi, Jun Ho Lee, So Yeon Jeon, Bo Kyung Sohn, Yu Kyeong Kim, Seong A Shin, Chul-Ho Sohn, Yu Jin Lee, Dong Young Lee, for the KBASE Research Group. Sleep experiences during different lifetime periods and in vivo Alzheimer pathologies. Alzheimer's Research & Therapy, Vol. 11(1), September 2019

• Chaewon Shin, Jee-Young Lee, Yu Kyeong Kim, Hyun Woo Nam, Eunjin Yoon, Seong A Shin, Han-Joon Kim, Beomseok Jeon. Cognitive decline in association with hyposmia in idiopathic rapid eye movement sleep behavior disorder: a prospective 2-year follow-up study. European Journal of Neurology, Vol. 26(11), June 2019

• Soowon Park, Taehoon Kim, Seong A Shin, Yu Kyeong Kim, Bo Kyung Sohn, Hyeon-Ju Park, Jung-Hae Youn, Jun-Young Lee. Corrigendum: behavioral and neuroimaging evidence for facial emotion recognition in elderly Korean adults with mild cognitive impairment, Alzheimer's disease, and frontotemporal dementia. Frontiers in Aging Neuroscience, Vol. 11(91), April 2019

• Jiyeon Lee, Jihyeon Kim, Seong A Shin, Soowon Park, Dong Hyun Yoon, Hongrae Kim, Yu Kyeong Kim, Min Kyong Moon, Bo Kyung Koo, Jun-Young Lee. Moderating Effect of Insulin Resistance on the Relationship between Gray Matter Volumes and Cognitive Function. Journal of Clinical Medicine, Vol. 7(11), November 2018

• Soowon Park, Suyeon Pyo, Seong A Shin, Ji Yeon Lee, Yu Kyeong Kim, Hyeon-Ju Park, Jung-Hae Youn, Sun-Won Park, Jun-Young Lee. A quick test of cognitive speed in older adults with Alzheimer's disease and mild cognitive impairment: A preliminary behavioral and brain imaging study. Psychiatry Research: Neuroimaging, Vol. 280, October 2018

• Dong Hyun Yoon, Jun-Young Lee, Seong A Shin, Yu Kyeong Kim, Wook Song. Physical Frailty and Amyloid-β Deposits in the Brains of Older Adults with Cognitive Frailty. Journal of Clinical Medicine, Vol. 7(7), July 2018

• Seung Kwan Kang, Seongho Seo, Seong A Shin, Min Soo Byun, Dong Young Lee, Yu Kyeong Kim, Dong Soo Lee, Jae Sung Lee. Adaptive template generation for amyloid PET using a deep learning approach. Human Brain Mapping, Vol. 39(9), September 2018

• Soowon Park, Taehoon Kim, Seong A Shin, Yu Kyeong Kim, Bo Kyung Sohn, Hyeon-Ju Park, Jung-Hae Youn, Jun-Young Lee. Behavioral and Neuroimaging Evidence for Facial Emotion Recognition in Elderly Korean Adults with Mild Cognitive Impairment, Alzheimer's Disease, and Frontotemporal Dementia. Frontiers in Aging Neuroscience, Vol. 9(389), November 2017

• Jung Hwan Shin, Seong A Shin, Jee-Young Lee, Hyunwoo Nam, Jae-Sung Lim, Yu Kyeong Kim. Precuneus degeneration and isolated apathy in patients with Parkinson's disease. Neuroscience Letters, Vol. 653, July 2017 (Co-first author)

• Soowon Park, Inhye Kim, Hyun Gyu Park, Seong A Shin, Youngsung Cho, Jung-Hae Youn, Yu Kyeong Kim, Jun-Young Lee. Development and Validation of the Rappel Indice-24: Behavioral and Brain Morphological Evidence. Journal of Geriatric Psychiatry & Neurology, Vol. 29(3), May 2016

• Jeong-Won Shin, Kon Chu, Seong A Shin, Keun-Hwa Jung, Soon-Tae Lee, Yoon-Sang Lee, Jangsup Moon, Doo Young Lee, Jae Sung Lee, Dong Soo Lee, Sang Keon Lee. Clinical Applications of Simultaneous PET/MR Imaging Using (R)-[11C]-Verapamil with Cyclosporin A: Preliminary Results on a Surrogate Marker of Drug-Resistant Epilepsy. AJNR American Journal of Neuroradiology, Vol. 37(4), April 2016

• Jae-Sung Lim, Seong A Shin, Jee-Young Lee, Hyunwoo Nam, Jun-Young Lee, Yu Kyeong Kim. Neural substrates of rapid eye movement sleep behavior disorder in Parkinson's disease. Parkinsonism & Related Disorders, Vol. 23, February 2016 (Co-first author)

• Yongjoon Yoo, Seong A Shin, Soowon Park, Ji-Hye Lee, Jung-Hae Youn, Yu Kyeong Kim, Jun-Young Lee. The Korean Size/Weight Attribute Test: A Semantic Knowledge Test for Korean Older Adults and Brain-Imaging Evidence. Journal of Alzheimer's Disease, Vol. 49(2), October 2015

• Euitae Kim, Oliver D Howes, Jin Woo Park, Seong A Shin, Bo-Hyung Kim, Federico E Turkheimer, Yun-Sang Lee, Jun Soo Kwon. Altered serotonin transporter binding potential in patients with obsessive-compulsive disorder under escitalopram treatment: [11C]DASB PET study. Psychological Medicine, Vol. 46(2), October 2015

Awards

• 2018

  Best Poster Award,12th International Conference on Alzheimer's Disease & Dementia

• 2016

  Best Poster Award, 4th International Conference on Molecular Neurodegeneration